By Marcus Adolphus Rothschild; Murray Oratz; Sidney S Schreiber
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Additional info for Alcohol and abnormal protein biosynthesis; biochemical and clinical
MUNRO, CHRISTINE HUBERT, AND B. SUREN BALIGA diurnal rhythmicity, which are difficult to interpret, especially since the data are given as uptake into protein per gram liver, and the liver loses weight during fasting. Waterlow et al.  have used a continuous infusion procedure and have found that fasting and feeding rats did not alter the uptake of label by liver protein ; since this was based on the specific activity of the liver protein, correction for the greater protein content of the liver after meals would alter the interpretation to show a stimulus.
Thus, adrenalectomy does not abolish the liver polysome aggregation response to amino acids [2 1 , 27]. Since there is an increase in cyclic AMP level after feeding protein to rats , glucagon might be involved. However, this does not seem to be the mediator controlling polysome function, since administration of glucagon does not affect liver polysome aggregation  and administration of insulin or car bohydrate has only a very delayed action on ribosome aggregation . Finally, as discussed below, aggregation occurs in response to amino acid supply to the perfused liver, when no changes in hormonal secretion can be involved.
Threonine, [26, 27]) so that they have very low levels in their livers of that amino acid. Van Venrooij et al.  found that ascites tumor cells showed a rapid loss of adenosine triphosphate (ATP) accompanying the slowing of protein synthesis when any one of 1 3 amino acids was deleted from the medium. However, changes in polysome aggregation occur in the liver from withdrawal of dietary protein without a concomitant reduction in adenine nucleotide levels  and in male rats, ethionine can deplete liver ATP extensively without significant inhibition of protein synthesis [75, 76] .
Alcohol and abnormal protein biosynthesis; biochemical and clinical by Marcus Adolphus Rothschild; Murray Oratz; Sidney S Schreiber
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